Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.
Hackett JA*, Huang Y*, Günesdogan U*, Gretarsson KA, Kobayashi T, Surani MA.
Nat Commun., 2018, 9 (1)
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GFP-labelled primordial germ cells in mouse embryos
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Genome-wide analysis of histone modifications and genomic interactions
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Differentiation of mouse embryonic stem cells towards primordial germ cell-like cells in vitro
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Heterogeneity in marmoset embryonic stem cells
Understanding Primordial Germ Cell Development
Our research focuses on understanding the development of mammalian primordial germ cells (PGCs). PGCs are the cells in the embryo that eventually give rise to sperm or egg. Accordingly, PGCs represent the only cell type responsible for the perpetuation of hereditary information across generations. After fertilisation of the egg, the resulting embryo starts to divide and shortly after implants into the uterus of the mother. During or after implantation, a few cells are set aside to become PGCs, which then activate a specific set of genes and modulate chemical modifications present on DNA. Our work addresses the fundamental questions: How are these molecular changes achieved and why are these required to form sperm and egg?Selected Publications
View all »NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Murakami K*, Günesdogan U*, Zylicz JJ, Tang WWC, Sengupta R, Kobayashi T, Kim S, Butler R, Dietmann S, Surani MA.
Nature, 2016, 529 (7586)
View on PubMed »Histone supply regulates S phase timing and cell cycle progression.
Günesdogan U, Jäckle H, Herzig A.
Elife, 2014, 9 (3)
View on PubMed »Latest News
View all »Elsa finished her Master’s thesis
Congrats!
Mila and Julia completed their Master’s thesis
Congratulations to Mila and Julia, who are the first students in our group to complete their thesis!
Cera secures fellowship
Many congratulations to Cera, who was awarded a PhD fellowship by the Boehringer Ingelheim Fonds!